Literature summary for 1.17.99.9 extracted from

Lewin, A.; Hederstedt, L.
Promoted evolution of a shortened variant of heme A synthase in the membrane of Bacillus subtilis (2008), FEBS Lett., 582, 1330-1334 .

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Protein Variants

Protein Variants	Comment	Organism
DELTA211-217	Bacillus subtilis LMT20R is deleted for the ctaA gene and, therefore, completely blocked in heme A synthesis. Plasmid pH216MS is obtained from plasmid pH216M (encoding the mutant CtaA-H216M) and carries a 21 bp deletion in ctaA. The CtaADELTA211-217 variant encoded by pH216MS is active in heme A synthesis and supports assembly of normal levels of cytochrome caa3	Bacillus subtilis
H216M	the H216M variant binds the enzyme substrate heme O, probably with methionine as an axial ligand, but is defective in heme A synthesis and accumulates a mono-hydroxylated reaction intermediate, heme I	Bacillus subtilis
H216M/DELTA211-217	Bacillus subtilis LMT20R is deleted for the ctaA gene and, therefore, completely blocked in heme A synthesis. Plasmid pH216MS is obtained from plasmid pH216M (encoding the mutant CtaA-H216M) and carries a 21 bp deletion in ctaA. The CtaADELTA211-217 variant encoded by pH216MS is active in heme A synthesis and supports assembly of normal levels of cytochrome caa3	Bacillus subtilis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	membrane protein with 8 transmembrane segments	Bacillus subtilis	16020	-

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	P12946	-	-
Bacillus subtilis 168	P12946	-	-

Synonyms

Synonyms	Comment	Organism
ctaA	-	Bacillus subtilis

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Release 2023.1 (January 2023)